抗血栓
溶栓
医学
血栓形成
靶向给药
抗凝剂
药理学
不利影响
纤溶剂
重症监护医学
药品
生物信息学
内科学
生物
心肌梗塞
作者
Lei Zhang,Zhen Li,Xianren Ye,Zhuo Chen,Zhe‐Sheng Chen
标识
DOI:10.1016/j.drudis.2021.04.023
摘要
Globally, the incidence of thromboembolic diseases has increased in recent years, accompanied by an increase in patient mortality. Currently, several targeting delivery strategies have been developed to treat thromboembolic diseases. In this review, we discuss the mechanisms of thrombolysis and current anticoagulant drugs, particularly those with targeting capability, highlighting advances in the accurate treatment of thrombolysis with fewer adverse effects. Such approaches include magnetic drug-loading systems combined with molecular imaging to recanalize blood vessels and systems based on chimeric Arg-Gly-Asp (RGD) sequences that can target platelet glycoprotein receptor. With such progress in targeted antithrombotic drugs, targeted thrombolysis treatment shows significant potential benefit for patients.
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