Preparation of ROS active and photothermal responsive hydroxyapatite nanoplatforms for anticancer therapy

Photothermal responsive nanoplatforms are attracting for photothermal therapy (PTT) of cancer. Herein, we propose a strategy to prepare IR-780 modified hydroxyapatite (HAP) nanorods as photothermic agents ([email protected]). The results demonstrated that the obtained [email protected] was photothermal responsive under near-infrared laser irradiation the photothermal conversion efficiency was 69.3%, and it remained photostability after 4 cycles of irradiation. This advantage overcomes the optical instability of IR780. MTT and cellular uptake research proved that [email protected] was biocompatible in appropriate concentration range (0–20 μg/mL) without laser irradiation. Concentration-dependent internalization and reactive oxygen species (ROS) related apoptosis of [email protected] for MCF-7 cells were observed. Animal experiments showed that the gathered [email protected] at the tumor site reached a photothermal responsive temperature up to 57.9 °C, which could almost ablate the tumor with volumes as large as 1500 mm3. In general, our photothermal material has good photothermal conversion characteristics, and may have the least safety problems while showing excellent therapeutic effects. Therefore, [email protected] has a brilliant prospect in the field of tumor photothermal therapy.