The Expression and Clinical Significance of NGF in Salivary Adenoid Cystic Carcinoma

Objective To study the expression and relationship of nerve growth factor(NGF) in the pathological types and perineural invasion of salivary adenoid cystic carcinoma(ACC) and its clinical significance. Methods The expressions of NGF was detected by S-P immunohistochemical method in 43 cases of human salivary adenoid cystic carcinoma tissues.Their relationships with the clinical pathological types,perineural invasion and survival were also analyzed. Results The positive expression of NGF had notably statistical significance with clinical pathological types of ACC(P0.05). The expressions of NGF in 23 cases with perineural invasion was significantly higher than that in 20 cases without perineural invasion(P0.05). Conclusion In human ACC, the expressions of NGF were closely correlated with clinical pathological types and perineural invasion of ACC. Detection of NGF protein may have protential effects on the prognosis of ACC.