Genetic Regulation of the Primordial Follicle Formation and Earliest Follicular Development

The regulatory of primordial follicle formation and earliest follicular development are important for mammalian oogenesis.Culture of primordial follicle in vitro was used to understand the regulatory mechanism of primordial follicle development.The transition from primordial to primary follicle is gonadotropin-independent,but regulated mainly by intraovarian factors,including Kit/KL,GDF9,KGF,NOBOX,AMH and so on.The study on regulatory mechanism of the primordial follicle formation and earliest follicular development is in mouse model mostly,but in large mammals and humans,only some aspects of follicle development have been studied because of the limited availability of suitable material for experimentation.In this review,recent research achievement on the regulatory mechanism of initiation of the primordial follicle development in mammals was reviewed,and the regulation of key factors on primordial follicle development was expounded,and study progress in mouse and other mammals in vitro culture was introduced.