The wastewater containing epichlorohydrin is high toxic and hard to be biodegraded,which is not fit for biological treatment.The oxidation process of Fenton reagent was put forward.The experiment explored the affecting factors and conditions of Fenton reagent.It was found that when pH was 3,H_2O_2 dosage was 1.92 g/L,Fe~(2+) dosage was 1.60 g/L,m(H_2O_2):m(Fe~(2+))was 1.2,Fe~(2+) was added twice by same dosage,and total reaction time was 1 hour,the removal rate of COD reached 89.44%.The treatment effect was improved greatly by fractionated adding reagents than once adding reagents.