Histopathological Observation on Hepatic lesions Induce by Cyclophosphamide in BALB/c Mice

Objective To investigate pathological lesions of liver induced by cyclophosphamide in BALB/c mice.Methods Cyclophosphamide was intraperitoneally administered to BALB/c mice in a dose 15 mg/kg once daily for 8 days.Eight days later, the mice were sacrificed and their livers were subjected to paraffin sections stained with hematoxylin and eosine to examine hepatic lesions under light microscopy.Results Some pathological lesions such as focal necrosis and interstitial inflammatory cell infiltration and so on were found in the liver tissue.Conclusion Cyclophosphamide can cause the considerable damage to the liver of BALB/c mice.