A comprehensive assessment of the gingival histohematic barrier components in patients with gingivitis and periodontitis was carried out. Analysis of the intratissular correlations has led the authors to a hypothesis on the presence of a peculiar 'break-off' of the interstructural relationships determined by the severity of the periodontal injury. Gingivitis is characterized by a change, though minimal, of correlations, as against the intact periodontium. Involvement of the entire tissue complex of the periodontium in the process is associated with elevation of the counts of both positive and negative relationships between free stromal cells. Accumulation of free stromal cells and disorder of their cooperation is parallel with lowering of alkaline phosphatase activity and isolation of polymorphonuclear leukocytes, this forming the structural basis for the progress of the inflammatory dystrophic process in the periodontium.