生物相容性
骨整合
材料科学
钛
润湿
接触角
表面改性
合金
钛合金
化学工程
扫描电子显微镜
X射线光电子能谱
纳米技术
冶金
复合材料
植入
外科
工程类
医学
作者
Xiang Li,Tao Chen,Jing Hu,Shujun Li,Qin Zou,Yunfeng Li,Nan Jiang,Hui Li,Jihua Li
标识
DOI:10.1016/j.colsurfb.2016.04.020
摘要
The Ti–24Nb–4Zr–7.9Sn titanium alloy (Ti2448) has shown potential for use in biomedical implants, because this alloy possesses several important mechanical properties, such as a high fracture strength, low elastic modulus, and good corrosion resistance. In this study, we aimed to produce a hierarchical nanostructure on the surface of Ti2448 to endow this alloy with favorable biological properties. The chemical composition of Ti2448 (64.0 wt% Ti, 23.9 wt% Nb, 3.9 wt% Zr, and 8.1 wt% Sn) gives this material electrochemical properties that lead to the generation of topographical features under standard anodic oxidation. We characterized the surface properties of pure Ti (Ti), nanotube-Ti (NT), Ti2448, and nanotube-Ti2448 (NTi2448) based on surface morphology (scanning electron microscopy and atomic force microscopy), chemical and phase compositions (X-ray diffraction and X-ray photoelectron spectroscopy), and wettability (water contact angle). We evaluated the biocompatibility and osteointegration of implant surfaces by observing the behavior of bone marrow stromal cells (BMSCs) cultured on the surfaces in vitro and conducting histological analysis after in vivo implantation of the modified materials. Our results showed that a hierarchical structure with a nanoscale bone-like layer was achieved along with nanotube formation on the Ti2448 surface. The surface characterization data suggested the superior biocompatibility of the NTi2448 surface in comparison with the Ti, NT, and Ti2448 surfaces. Moreover, the NTi2448 surface showed better biocompatibility for BMSCs in vitro and better osteointegration in vivo. Based on these results, we conclude that anodic oxidation facilitated the formation of a nanoscale bone-like structure and nanotubes on Ti2448. Unlike the modified titanium surfaces developed to date, the NTi2448 surface, which presents both mechanical compatibility and bioactivity, offers excellent biocompatibility and osteointegration, suggesting its potential for use in orthopedic applications.
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