经颅直流电刺激
医学
失语症
冲程(发动机)
随机对照试验
生活质量(医疗保健)
物理疗法
听力学
物理医学与康复
刺激
内科学
精神科
机械工程
护理部
工程类
作者
Melissa D. Stockbridge,Jordan J Elm,Bonnie L. Breining,Donna C. Tippett,Rajani Sebastian,Christy Cassarly,Abeba Teklehaimanot,Leigh Ann Spell,Shannon M. Sheppard,Emilia Vitti,Kristina Ruch,Emily B Goldberg,Catherine Kelly,Lynsey M. Keator,Julius Fridriksson,Argye E. Hillis
出处
期刊:Stroke
[Ovid Technologies (Wolters Kluwer)]
日期:2023-03-13
卷期号:54 (4): 912-920
标识
DOI:10.1161/strokeaha.122.041557
摘要
Transcranial direct-current stimulation (tDCS) is a promising adjunct to therapy for chronic aphasia.This single-center, randomized, double-blind, sham-controlled efficacy trial tested the hypothesis that anodal tDCS augments language therapy in subacute aphasia. Secondarily, we compared the effect of tDCS on discourse measures and quality of life and compared the effects on naming to previous findings in chronic stroke. Right-handed English speakers with aphasia <3 months after left hemisphere ischemic stroke were included, unless they had prior neurological or psychiatric disease or injury or were taking certain medications (34 excluded; final sample, 58). Participants were randomized 1:1, controlling for age, aphasia type, and severity, to receive 20 minutes of tDCS (1 mA) or sham-tDCS in addition to fifteen 45-minute sessions of naming treatment (plus standard care). The primary outcome variable was change in naming accuracy of untrained pictures pretreatment to 1-week posttreatment.Baseline characteristics were similar between the tDCS (N=30) and sham (N=28) groups: patients were 65 years old, 53% male, and 2 months from stroke onset on average. In intent-to-treat analysis, the adjusted mean change from baseline to 1-week posttreatment in picture naming was 22.3 (95% CI, 13.5-31.2) for tDCS and 18.5 (9.6-27.4) for sham and was not significantly different. Content and efficiency of picture description improved more with tDCS than sham. Groups did not differ in quality of life improvement. No patients were withdrawn due to adverse events.tDCS did not improve recovery of picture naming but did improve recovery of discourse. Discourse skills are critical to participation. Future research should examine tDCS in a larger sample with richer functional outcomes.URL: https://www.gov; Unique identifier: NCT02674490.
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