Aptamer-modified Zr-MOFs to construct nanocatalysts with engineered specificity toward paraoxon

Aptamer-modified Zr-MOFs (UiO-66-APT) were constructed as nanocatalysts for achieving specific hydrolysis of paraoxon. The conjunction mode of the aptamer on the Zr-MOFs affected the binding of the substrates with the catalytic sites, thus leading to different catalytic activities. This study provides a solution for achieving specific catalysis of nanocatalysts, just like that in natural enzymes.