医学
随机对照试验
科克伦图书馆
布比卡因
荟萃分析
骨科手术
恶心
麻醉
关节置换术
呕吐
全膝关节置换术
内收肌管
术后恶心呕吐
外科
内科学
作者
Jian-Jiun Chen,Yun-Che Wu,Jun‐Sing Wang,Cheng-Hung Lee
标识
DOI:10.1186/s13018-023-03699-4
摘要
Liposomal bupivacaine (LB) is a relatively new formulation that slowly releases bupivacaine to extend its efficacy for 72-96 h. It is inconclusive whether LB offers better efficacy than traditional periarticular injection (TPAI) following total knee arthroplasty (TKA).Relevant randomized controlled trials (RCTs) were searched using electronic databases, including PubMed, Cochrane Library, EMBASE, and Web of Science. Review Manager 5.4.1 was used for calculations.Sixteen RCTs were included in this meta-analysis. LB had better effects on morphine consumption equivalents during postoperative 24-48 h than TPAI. No significant difference was observed in pain relief, incidence of nausea and vomiting, or length of hospital stay between the two groups.LB administration during TKA is not superior to TPAI. Studies with larger sample size are needed to validate our findings. PROSPERO registration number: CRD42022355094.
科研通智能强力驱动
Strongly Powered by AbleSci AI