Altered microglial polarization reduces demyelination in cerebellar slices treated with serum from CD20-depleted multiple sclerosis patients

Depletion of CD20 positive cells via OFT appears to indirectly prevent demyelination by modulating microglial polarization. This is linked to reduced serum cytokines and absence of serum-inherent TLR4 ligands post-treatment, suggesting a potential peripheral immunomodulation-mediated protective mechanism impacting CNS immune responses. These findings underscore the need to investigate how therapies targeting peripheral immune cells can also influence CNS immune mechanisms.