再生(生物学)
神经导管
坐骨神经
轴突
周围神经损伤
周围神经
生物医学工程
神经外膜修复
电气导管
材料科学
桥接(联网)
生长锥
组织工程
神经损伤
神经营养因子
毛细管作用
外围设备
解剖
神经营养素
神经生长因子
再生医学
雪旺细胞
轴突引导
医学
外周神经系统
生物相容性材料
神经科学
作者
Dongwei Lan,Yizhou Xie,Meng Lei,Bo Deng,Xueyong Xie,Lan Chen,Haoyu Wang,Xueliang Liu,Feng Xu,Wei Zhao
标识
DOI:10.1002/adma.202516449
摘要
Long-gap peripheral nerve injury (PNI) presents a significant challenge since the growth cone at the proximal end fails to detect and respond to neurotrophic signals from the distal ends, even when bridging the long-gap with nerve guide conduits (NGCs), impeding the motivated growth of new axons. In this study, a bioinspired force-inducible multichannel nerve guide conduit (FI-MNGC) is developed, constructed from silk fibrin-based hydrogel. By mimicking the gradient capillary architectures in vascular plants, the FI-MNGC utilizes a multichannel design with gradient apertures that can self-generate enhanced capillary forces, which not only promote directed axon growth but also guide the directed delivery of Schwann cells (SCs) toward the distal ends of the injured nerve, without the need for any external stimuli. Implemented in a rat model with a 16 mm and a rabbit model with a 30 mm long-gap sciatic nerve defect, the FI-MNGC significantly accelerates the recovery process, paralleling the efficacy of autografts in nerve regeneration, functional recovery, and repair speed. This innovative approach offers a promising alternative to autografts, enhancing the potential for clinical implementation in long-gap PNI therapies.
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