材料科学
纳米片
检出限
唾液
介孔材料
电化学
催化作用
选择性
人口
纳米技术
电极
色谱法
化学
物理化学
人口学
社会学
生物化学
作者
Shunji Chen,Hui Huang,Haiming Sun,Qiunan Liu,Huichao Zhu,Jian Zhao,Pengbo Liu,Jun Yu
标识
DOI:10.1021/acsami.2c17325
摘要
Noninvasive detection of glucose (NGD) is important because ∼10% of the global population is suffering from diabetes. Herein, a three-dimensional (3D) micro-/mesoporous structure, i.e., a CoNi-N nanosheet-coated GaN 3D scaffold (CoNi-N@GaN-3S), was proposed for detecting saliva glucose, where the GaN scaffold can provide a large open surface for nanosheet decoration, while the catalytic nanosheets can increase the surface area and prevent the GaN-3S from anodic corrosion. Moreover, it was found that high-temperature ammoniation of CoNi can lead to dense atomic holes and an N-terminated surface (CoNi-N), which promoted the ionization of CoNi with a higher catalytic activity. It is the first time that dense atomic holes have been observed in CoNi to our knowledge. The designed CoNi-N@GaN-3S sensor was applied to the electrochemical detection of glucose with a low limit of detection (LOD) of 60 nM and a high sensitivity, selectivity, and stability. In addition, detection of human-saliva glucose was realized with an LOD of 5 μM, which was more than 4-fold lower than reported reliable LODs. An integrated sensor with a low consumption of saliva sample was demonstrated for NGD.
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