Transition Metal Oxide‐Decorated MXenes as Drugless Nanoarchitectonics for Enriched Nanocatalytic Chemodynamic Treatment

Abstract Despite their unique characteristics, 2D MXenes with sole photothermal conversion ability are required to explore their superfluous abilities in biomedicine. The small‐molecule‐based chemotherapeutics suffer from various shortcomings of time‐consuming and expensiveness concerning theoretical and performance (preclinical/clinical) checks. This study demonstrates the fabrication of Ti 3 C 2 MXene nanosheets (TC‐MX NSs) and subsequent decoration with transition metal oxides, that is, copper oxide (Cu 2 O/MX, CO‐MX NCs) as drugless nanoarchitectonics for synergistic photothermal (PTT)–chemodynamic therapeutic (CDT) efficacies. Initially, the monolayer/few‐layered TC‐MX NSs are prepared using the chemical etching‐assisted ultrasonic exfoliation method and then deposited with Cu 2 O nanoconstructs using the in situ reduction method. Further, the photothermal ablation under near‐infrared (NIR)‐II laser irradiation shows PTT effects of CO‐MX NCs. The deposited Cu 2 O on TC‐MX NSs facilitates the release of copper (Cu + ) ions in the acidic microenvironment intracellularly for Fenton‐like reaction‐assisted CDT effects and enriched PTT effects synergistically. Mechanistically, these deadly free radicals intracellularly imbalance the glutathione (GSH) levels and result in mitochondrial dysfunction, inducing apoptosis of 4T1 cells. Finally, the in vivo investigations in BALB/c mice confirm the substantial ablation of breast carcinoma. Together, these findings demonstrate the potential synergistic PTT–CDT effects of the designed CO‐MX NCs as drugless nanoarchitectonics against breast carcinoma.