上睑下垂
坏死性下垂
程序性细胞死亡
免疫学
生物
免疫
先天免疫系统
中性粒细胞胞外陷阱
细胞凋亡
信号转导
免疫系统
细胞生物学
炎症
遗传学
作者
Hai-Yue Tu,Haoyu Ren,Junjie Jiang,Changshun Shao,Yufang Shi,Peishan Li
标识
DOI:10.1002/advs.202306457
摘要
Abstract Neutrophils, accounting for ≈70% of human peripheral leukocytes, are key cells countering bacterial and fungal infections. Neutrophil homeostasis involves a balance between cell maturation, migration, aging, and eventual death. Neutrophils undergo different death pathways depending on their interactions with microbes and external environmental cues. Neutrophil death has significant physiological implications and leads to distinct immunological outcomes. This review discusses the multifarious neutrophil death pathways, including apoptosis, NETosis, pyroptosis, necroptosis, and ferroptosis, and outlines their effects on immune responses and disease progression. Understanding the multifaceted aspects of neutrophil death, the intersections among signaling pathways and ramifications of immunity will help facilitate the development of novel therapeutic methods.
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