Acne is a condition of the pilosebaceous glands of skin characterized by anomalies in the production of sebum which includes both non-inflammatory lesions such as comedones (open and closed) and inflammatory lesions like pustules, papules and nodules. Patients with acne frequently seek treatment in inflammatory lesions state. Haridradya Taila is a classical preparation mentioned in kshudra rogadhikar of Chakradatta. The present study aimed to evaluate the safety and efficacy of haridradya taila in acne and acne induced post inflammatory hyperpigmentation. Total fifty patients in the age group of 18–45 years having mild to moderate acne and acne induced post inflammatory hyperpigmentation were enrolled. The statistical significance of the data was examined using SPSS. Clinical trial results were statistically significant for acne and acne induced post inflammatory hyperpigmentation. The results of this study suggest Haridradya Taila is safe and effective in the treatment of mild to moderate acne and acne induced post inflammatory hyperpigmentation.