化学
正电子发射断层摄影术
荧光
碳酸酐酶
分子成像
细胞内
荧光寿命成像显微镜
Pet成像
生物化学
酶
核医学
体内
医学
生物
物理
量子力学
生物技术
作者
Nerella Sridhar Goud,Priti Singh,Pavitra S. Thacker,Mohammed Arifuddin,Claudiu T. Supuran
标识
DOI:10.1016/j.bioorg.2023.106399
摘要
Positron emission tomography (PET) and fluorescent imaging play a pivotal role in medical diagnosis, biomedical oncologic research, and drug development process, which include identification of target location, target engagement, but also prove on mechanism of action or pharmacokinetics of new drug candidates. PET estimates physiological changes at the molecular level using specific radiotracers containing a short-lived positron emitting radionuclide such as fluorine-18 or carbon-11, whereas fluorescent imaging techniques use fluorescent probes labeled with suitable drug candidates for detection at the molecular level. The human carbonic anhydrase (hCA) isoforms IX and XII are overexpressed in hypoxic cancer cells, promoting tumor growth by regulating extra/intracellular pH, ferroptosis, and metabolism, being recognized as promising targets for anticancer theranostic agents. In this review, we have focused on PET radiotracers as well as fluorescent probes for diagnosis and treatment of tumors expressing hCA IX and hCA XII.
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