Intrauterine Hyperglycemia Induces SIRT3-mediated Mitochondrial Dysfunction: The Fetal Origin Pathogenesis of Precocious Osteoarthritis

Diabetes and other metabolic and inflammatory comorbidities are highly associated with osteoarthritis (OA). However, whether early-life hyperglycemia exposure affects susceptibility to long-term OA is still unknown. The purpose of this study was to explore the fetal origins of OA and provide insights into early-life safeguarding for individual health.