Emerging Technologies to Enhance Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells: Focus on Nanomaterials and Bioactive Compounds

Bone tissue damage and associated disorders significantly compromise the quality of life of affected patients, and existing therapeutic options remain limited. Bone marrow mesenchymal stem cells (BMSCs) play a crucial role in bone regenerative medicine, owing to their ability to differentiate into osteoblasts. Utilizing cutting-edge technologies, nanomaterials, and bioactive compounds can emulate the natural bone tissue microenvironment, offer a three-dimensional scaffold that facilitates the osteogenic differentiation of BMSCs, and modulate signals at the molecular level, thereby showing promise for applications in bone regeneration and repair. This review seeks to discuss the latest research advancements, elucidate the underlying mechanisms, and highlight the potential benefits of these technologies in augmenting the osteogenic capacity of BMSCs. Furthermore, the challenges and future directions for integrating these technologies in practical settings are discussed to pioneer new vistas in bone regenerative medicine.