Novel Triazole-Substituted Imidazo[1,2-a]Pyrimidine Compounds as cGAS inhibitors

This patent application presents the discovery and characterization of a novel series of triazole-substituted imidazo[1,2-a]pyrimidine compounds as selective cGAS inhibitors. These compounds effectively suppress cGAS enzymatic activity and modulate downstream STING signaling, demonstrating potential for treating autoimmune and inflammatory diseases driven by aberrant cytosolic DNA sensing.