An activatable endoplasmic reticulum-targeted probe for NIR imaging-guided photothermal therapy

An H₂O₂-activated, endoplasmic reticulum-targeted theranostic probe was developed. This designed probe could be activated by H₂O₂, resulting in increased NIR fluorescence and photothermal signals, thus achieving specific recognition of H₂O₂ and further photothermal therapy in the endoplasmic reticulum of H₂O₂-overexpressing cancer cells.