神经炎症
冲程(发动机)
医学
免疫系统
神经科学
病态的
机制(生物学)
缺血性中风
炎症
小胶质细胞
生物信息学
免疫学
缺血
心理学
内科学
生物
哲学
工程类
认识论
机械工程
作者
Juan Gao,Jifei Liu,Yonghong Li,Junxi Liu,He Wang,Miao Chai,Ying Dong,Zhenchang Zhang,Gang Su,Manxia Wang
摘要
Ischemic stroke (IS) is characterized by high incidence, high recurrence, and high mortality and places a heavy burden on society and families. The pathological mechanisms of IS are complex, among which secondary neurological impairment mediated by neuroinflammation is considered to be the main factor in cerebral ischemic injury. At present, there is still a lack of specific therapies to treat neuroinflammation. The tumor suppressor protein p53 has long been regarded as a key substance in the regulation of the cell cycle and apoptosis in the past. Recently, studies have found that p53 also plays an important role in neuroinflammatory diseases, such as IS. Therefore, p53 may be a crucial target for the regulation of the neuroinflammatory response. Here, we provide a comprehensive review of the potential of targeting p53 in the treatment of neuroinflammation after IS. We describe the function of p53, the major immune cells involved in neuroinflammation, and the role of p53 in inflammatory responses mediated by these cells. Finally, we summarize the therapeutic strategies of targeting p53 in regulating the neuroinflammatory response after IS to provide new directions and ideas for the treatment of ischemic brain injury.
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