立体中心
炔丙基
芳基
对映选择合成
化学
催化作用
镍
电泳剂
碘化物
背景(考古学)
组合化学
有机化学
烷基
古生物学
生物
作者
Youxiang Jin,Hao Wen,Feiyan Yang,Decai Ding,Chuan Wang
出处
期刊:ACS Catalysis
日期:2021-10-19
卷期号:11 (21): 13355-13362
被引量:19
标识
DOI:10.1021/acscatal.1c04143
摘要
In this context, we report the successful application of a cross-electrophile strategy in the synthesis of multisubstituted allenes. Under the catalysis of nickel, reductive cross-coupling between propargyl carbonates and organoiodides provides an entry to prepare tri- or tetrasubstituted allenes without employing any pregenerated organometallics. Furthermore, propargyl carbonates also prove to be suitable allenylating agents in nickel-catalyzed asymmetric reductive aryl-allenylation of aryl-iodide-tethered unactivated alkenes, furnishing a variety of chiral benzene-fused cyclic compounds bearing a quaternary allenyl-substituted stereogenic center in a highly enantioselective manner.
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