纳米反应器
葡萄糖氧化酶
材料科学
纳米技术
过氧化氢
酶
癌症治疗
催化作用
癌细胞
癌症治疗
组合化学
癌症
生物传感器
化学
有机化学
纳米颗粒
生物
遗传学
作者
Pengli Gao,Shuang Chen,Shi Liu,Hongxin Liu,Zhigang Xie,Min Zheng
标识
DOI:10.1021/acsami.1c16091
摘要
As a class of functional proteins, enzymes possess inherent insignificant features, for instance, mediocre stability and membrane impermeability and reduced enzymatic activity after modification, which partly limit their biomedical applications. Thus, it is indispensable to exploit robust nanoreactors with high enzymatic activity and good stability and cell permeability. Here, the chiral carbon dots (CDs)-glucose oxidase (GOx) nanoreactors named LGOx and DGOx were constructed by the coassembly of GOx with L/D-CDs, respectively. L/DGOx can significantly enhance the activity of GOx and improve the efficient delivery of GOx to cancer cells. Moreover, these nanoreactors can generate hydrogen peroxide to efficaciously kill cancer cells and restrain tumor growth, and DGOx exhibits higher enzymatic activity than LGOx. According to our understanding, this is the first report about utilizing chiral CDs as vectors to construct effective CDs-enzyme nanohybrids for cancer therapy, which is envisioned to be a versatile strategy for multitudinous biomedical applications.
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