Multifaceted microglia — key players in primary brain tumour heterogeneity

Microglia are the resident innate immune cells of the immune-privileged CNS and, as such, represent the first line of defence against tissue injury and infection. Given their location, microglia are undoubtedly the first immune cells to encounter a developing primary brain tumour. Our knowledge of these cells is therefore important to consider in the context of such neoplasms. As the heterogeneous nature of the most aggressive primary brain tumours is thought to underlie their poor prognosis, this Review places a special emphasis on the heterogeneity of the tumour-associated microglia and macrophage populations present in primary brain tumours. Where available, specific information on microglial heterogeneity in various types and subtypes of brain tumour is included. Emerging evidence that highlights the importance of considering the heterogeneity of both the tumour and of microglial populations in providing improved treatment outcomes for patients is also discussed. Microglia are the first immune cells to encounter a developing primary brain tumour and have both tumour-supporting and antitumour effects. Here, Keane et al. consider the emerging evidence indicating that tumour-associated macrophages and microglia influence tumour initiation and progression as well as responses to therapy.