Post-concussion syndrome is no longer an accepted medical term and has been replaced by the phrase “persistent post-concussive symptoms” or simply “persistent symptoms.” Post-concussion syndrome had been used to identify individuals with prolonged symptoms following concussion, but the term assumed that concussion is a homogeneous process and that persistent symptoms were always a manifestation of the original brain injury. Concussion often manifests in different clinical domains, and it is important that these domains be managed more specifically. Domain-specific interventions seek to address the somatic, cognitive, and emotional issues that are common following concussion. Such specific interventions mitigate the development of persistent symptoms.