[Toxicological characteristics of Ochratoxin A and its impact on male reproduction].

Ochratoxin A (OTA) is found not only nephrotoxic, teratogenic, neurotoxic, and immunotoxic, but also reprotoxic for human and animals. In the recent decade, more attention has been paid to the impact of OTA on human reproduction and the studies of its underlying mechanisms. Many studies show that OTA affects the function of the reproductive system by acting as an endocrine disrupter and, as a testicular toxin, decreases sperm quality and even induces testis cancer. This review summarizes the toxicological characteristics and toxicokinetic process of OTA as well as recent progress in the studies of various toxic effects of OTA and their underlying mechanisms, hoping to call the attention from more people to the toxicity of OTA to male reproductive health.赭曲霉毒素A（OTA）对人类和动物具有肾毒性、致畸毒性、神经毒性和免疫毒性等，最近十几年不断被证明还具有生殖毒性。因此，人们已经开始重视OTA对人类生殖健康的危害，并对其损害生殖健康的发生途径和分子机制进行了研究。研究证明，OTA可作为机体内的一种内分泌干扰物影响生殖系统的功能。对雄性动物和男性来说，OTA是一种睾丸毒素，可降低精子质量，还可能诱发睾丸癌变。基于上述内容，本文首先阐述了OTA的毒理学特征及毒代动力学过程，然后集中讨论了OTA引发的各种毒害作用的机理及研究进展。总之，OTA对雄性生殖健康的危害不容小觑，本文旨在引起人们对OTA危害雄性生殖健康的重视。.