赖氨酰氧化酶
羟脯氨酸
白藜芦醇
四氯化碳
四氯化碳
肝纤维化
药理学
医学
纤维化
化学
内分泌学
内科学
癌症研究
酶
生物化学
有机化学
作者
Roohollah Mohseni,Zahra Arab Sadeghabadi,Mohammad Taghi Goodarzi,Jamshid Karimi
标识
DOI:10.1080/08923973.2019.1688829
摘要
Objectives: In the current study, we aimed to investigate the effect of administration of resveratrol (RES) and beta-aminopropionitrile (BAPN) separately and together on the liver fibrosis progression via regulation of the gene expression and protein level of lysyl oxidase (LOX).Materials and methods: The six-week old Wistar rats received carbon tetrachloride (CCl4) intraperitoneally and RES and BAPN were administrated orally for eight weeks. The hepatoprotective effects of RES, BAPN, and combination treatment were evaluated. Then the hepatic protein and gene expression levels of LOX were measured.Results: Both RES and BAPN showed the antifibrotic effect through the reduction of collagen fiber bundles, hepatic hydroxyproline content, and protein level of LOX. The antifibrotic effect increased when RES and BAPN up-taken together.Conclusion: The co-administration of RES and BAPN can be considered as a promising therapeutic approach via targeting LOX.
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