Impact of continous positive airway pressure therapy on exhaled nitic oxide in obstructive sleep apnea syndrome

Background: OSAS was as­sociated with upper and lower respira­tory tracts inflammation, Fractional exhaled nitric oxide (FeNO) proposed as a marker of airway inflammation, few studies were done on impact of continuous positive airway pressure (CPAP) on FeNO . Aim of the Work: to study the impact of continues positive airway pressure therapy on exhaled NO as marker of inflammation in obstructive sleep apnea syndrome. Patient and Methods: This study is acase control study including (27) participants were newly diagnosed as OSA and (9) control recruited from sleep outpatient clinic, full night PSG was done, fractional exhaled nitric oxide and HsCRP were measured next morning of PSG, CPAP for moderate to severe OSA patient was advised with measurement of FENOand HsCRP after 3months of CPAP Results: there were statistically significant higher FeNO and S.CRP in OSA patients versus control group. there were statistically significant decrease in both FeNO and serum CRP after 3months of CPAP therapy. Conclusion: upper airway and systemic inflammation are present in OSAS, indicated by increasing both FENO and serum CRP, CPAP therapy reduced Fractional exhaled nitric oxide(FeNO)level and S.CRP in OSA patients