Long‐Term Continuous Glucose Monitoring Using a Fluorescence‐Based Biocompatible Hydrogel Glucose Sensor

Abstract Fluorescence‐based hydrogel glucose sensors with boronic acid‐based glucose recognition are promising regarding their potential to improve continuous glucose monitoring by facilitating long‐lasting accuracy. However, these sensors typically become encapsulated after implantation, and the dynamic range decreases following long‐term implantation and use. Herein, a four‐arm polyethylene glycol (PEG) hydrogel is developed with an immobilized glucose‐responsive fluorescence dye (GF‐PEG‐gel); this hydrogel is effective in mitigating foreign body reactions (FBRs) that hinder stable glucose responses in vivo. The GF‐PEG‐gel attached to an implantable device successfully traces blood glucose concentrations in diabetic model rats for 45 days. A pig experiment shows that the device measures the glucose concentration with an equivalent accuracy to that required for clinically available settings.