适体
生物传感器
纳米技术
化学
纳米材料
生物分子
结合
材料科学
生物
分子生物学
数学
数学分析
作者
Xiaoqi Tao,Xin Wang,Biwu Liu,Juewen Liu
标识
DOI:10.1016/j.bios.2020.112537
摘要
Nanozymes are engineered nanomaterials with enzyme-like activities. Over the past decade, impressive progresses on nanozymes in biosensing have been made due to their unique advantages of high stability, low cost, and easy modification compared to natural enzymes. For many biosensors, it is critical to conjugate nanozymes to affinity ligands such as antibodies and aptamers. Since different nanomaterials have different surface properties, conjugation methods need to be compatible with these properties. In addition, the effect of biomolecules on nanozyme activity needs to be considered. In this review, we first categorized nanozyme-based biosensors into four parts, respectively describing noncovalent and covalent modifications with antibodies and aptamers. Meanwhile, recent advances in antibody and aptamer labeled nanozyme biosensors are summarized, and the methods of their conjugation are further illustrated. Finally, conclusions and future perspectives for the development and application of nanozyme bioconjugates are discussed.
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