氢胺化
化学
区域选择性
小学(天文学)
组合化学
催化作用
氨
胺气处理
有机化学
天文
物理
作者
Yi‐Dan Du,Bi-Hong Chen,Wei Shu
标识
DOI:10.1002/anie.202016679
摘要
Abstract Direct and selective synthesis of primary amines from easily available precursors is attractive yet challenging. Herein, we report the rapid synthesis of primary amines from alkenes via metal‐free regioselective hydroamination at room temperature. Ammonium carbonate was used as ammonia surrogate for the first time, allowing for efficient conversion of terminal and internal alkenes into linear, α‐branched, and α‐tertiary primary amines under mild conditions. This method provides a straightforward and powerful approach to a wide spectrum of advanced, highly functionalized primary amines which are of particular interest in pharmaceutical chemistry and other areas.
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