共价键
化学
表面改性
表面电荷
粒子(生态学)
原子力显微镜
显微镜
纳米技术
化学力显微镜
胶体
开尔文探针力显微镜
化学物理
化学工程
材料科学
非接触原子力显微镜
有机化学
物理化学
光学
物理
地质学
工程类
海洋学
出处
期刊:BioTechniques
[Future Science Ltd]
日期:2020-11-01
卷期号:69 (5): 363-370
被引量:7
标识
DOI:10.2144/btn-2020-0085
摘要
Two important viral surface characteristics are the hydrophobicity and surface charge, which determine the viral colloidal behavior and mobility. Chemical force microscopy allows the detection of viral surface chemistry in liquid samples with small amounts of virus sample. This single-particle method requires the functionalization of an atomic force microscope (AFM) probe and covalent bonding of viruses to a surface. A hydrophobic methyl-modified AFM probe was used to study the viral surface hydrophobicity, and an AFM probe terminated with either negatively charged carboxyl acid or positively charged quaternary amine was used to study the viral surface charge. With an understanding of viral surface properties, the way in which viruses interact with the environment can be better predicted.
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