材料科学
纳米技术
涂层
纳米颗粒
表面工程
活力测定
组织工程
化学工程
曲面(拓扑)
化学
生物物理学
金属
作者
Wen Li,Wei Bing,Sa Huang,Jinsong Ren,Xiaogang Qu
标识
DOI:10.1002/adfm.201500039
摘要
Inspired by the load-bearing biostructures in nature, a multifunctional shell for encapsulating cell using the polyphenol-metal complexes is fabricated. the artificial shell is formed by cross-linking of tannic acid and iron ion on cell surface. it can protect cells from unfriendly environments, including uv light irradiation and reactive oxygen damage. with the hybrid property of polyphenol and metal liands, the shell provides a versatile platform for cell surface engineering. the magnetic nanoparticles, dna molecules, as well as the magnetic resonance imaging agents are easily incorporated into the shell. more interestingly, unlike the traditional passive coatings, here the shell can be controllably disassembled under external stimuli. the dynamic coating is used as a reversible element to regulate cell division and surface modification. the cell viability and protein expression experiments further confirm that the shell formation and degradation processes are biocompatible. this multifunctional coating strategy is applicable to multiple living cell types, including yeast cells, escherichia coli bacteria, and mammalian cells. therefore, this platform would be useful for living cell based fundamental research and biological applications.
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