H3K27-specific demethylase orchestrates the phenotypic and functional plasticity of intestinal ILC3s

ILC3 deficit and normalizes cytokine production, positioning TCF7 as the key effector downstream of UTX. These findings establish UTX/JMJD3 as central epigenetic gatekeepers of mucosal immunity, offering therapeutic avenues for inflammatory disorders driven by ILC3 dysregulation.