Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

competitively reversed Cer24:1's protective effects, further supporting EP2-dependent modulation. Our results reveal Cer24:1 as an endogenous pro-resolving lipid that constrains neutrophilic inflammation via direct modulation of the EP2-STAT3 axis in Th17 cells, providing a new metabolic checkpoint and potential therapeutic strategy for severe neutrophilic asthma.