Radiomics refers to the extraction and analysis of a large amounts of advanced quantitative imaging features from medical images, for diagnosis and treatment of diseases. The concept was born less than five years, but has become a research hotspot in global clinical medicine and biomedical engineering. The research of radiomics involves the screening, diagnosis, treatment, and evaluation of several types of tumors, and has achieved considerably optimistic results. Radiomics, which will obtain more standard, stable features and complete validation based on multicenter research, may be applied in precision oncology from evidence-based medicine hereafter. In this paper, a systematic and comprehensive exposition of radiomics in the past, present and future is given.