尾部悬挂试验
丹皮酚
行为绝望测验
开阔地
药理学
脂多糖
原肌球蛋白受体激酶B
海马体
化学
肿瘤坏死因子α
海马结构
神经营养因子
内分泌学
内科学
医学
抗抑郁药
受体
替代医学
病理
作者
Weiwei Tao,Hanqing Wang,Qiang Su,Yanyan Chen,Wenbo Xue,Baomei Xia,Jin‐Ao Duan,Gang Chen
标识
DOI:10.1016/j.psychres.2016.02.033
摘要
The present study was designed to detect the anti-depressant effects of paeonol and the possible mechanisms in the lipopolysaccharide-induced depressive-like behavior. Open-field test(OFT), tail suspension test(TST) and forced swimming test(FST) were used to evaluate the behavioral activity. The contents of 5-hydroxytryptamine (5-HT) and norepinephrine (NE) in mice hippocampus were determined by HPLC-ECD. Serum interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α levels were evaluated by enzyme-linked immunosorbent assay (ELISA). Our results showed that LPS significantly decreased the levels of 5-HT and NE in the hippocampus. LPS also reduced open-field activity, as well as increased immobility duration in FST and TST. Paeonol administration could effectively reverse the alterations in the concentrations of 5-HT, NE and reduce the IL-6 and TNF-α levels. Moreover, paeonol effectively downregulated brain-derived neurotrophic factor (BDNF), tropomyosin-related kinase B (TrkB) and Nuclear factor-κB (NF-κB) in hippocampal. In conclusion, paeonol administration exhibited significant antidepressant-like effects in mice with LPS-induced depression.
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