医学
脑梗塞
谷氨酰胺
冲程(发动机)
代谢组学
生物标志物
内科学
尿
心脏病学
生物信息学
生物化学
缺血
氨基酸
生物
机械工程
工程类
作者
Jeeyoun Jung,Ho-Sub Lee,Kang Dh,No Soo Kim,Min Ho,Ok‐Sun Bang,Do Hyun Ryu,Geum‐Sook Hwang
出处
期刊:Stroke
[Ovid Technologies (Wolters Kluwer)]
日期:2011-05-01
卷期号:42 (5): 1282-1288
被引量:167
标识
DOI:10.1161/strokeaha.110.598789
摘要
Stroke is one of the leading causes of adult disability and death in developing countries. However, early diagnosis is difficult and no reliable biomarker is currently available. Thus, we applied a 1H-NMR metabolomics approach to investigate the altered metabolic pattern in plasma and urine from patients with cerebral infarctions and sought to identify metabolic biomarkers associated with stroke.Metabolic profiles of plasma and urine from patients with cerebral infarctions, especially small vessel occlusion, were investigated using 1H-NMR spectroscopy coupled with multivariate statistical analysis, such as principal components analysis and orthogonal partial least-squares discriminant analysis.Multivariate statistical analysis showed a significant separation between patients and healthy individuals. The plasma of stroke patients was characterized by the increased excretion of lactate, pyruvate, glycolate, and formate, and by the decreased excretion of glutamine and methanol; the urine of stroke patients was characterized by decreased levels of citrate, hippurate, and glycine. These metabolites detected from plasma and urine of patients with cerebral infarctions were associated with anaerobic glycolysis, folic acid deficiency, and hyperhomocysteinemia. Furthermore, the presence of cerebral infarction in the external validation model was predicted with high accuracy.These data demonstrate that a metabolomics approach may be useful for the effective diagnosis of cerebral infarction and for the further understanding of stroke pathogenesis.
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