免疫系统
免疫学
生物标志物
肺炎
淋巴细胞
中性粒细胞与淋巴细胞比率
医学
疾病
败血症
人口
免疫
免疫状态
生物信息学
生物
内科学
生物化学
环境卫生
作者
Agata Buonacera,Benedetta Stancanelli,Michele Colaci,Lorenzo Malatino
摘要
Over the last 10 years, the evaluation of the neutrophil-to-lymphocyte ratio (NLR) as an emerging marker of diseases has become a compelling field of bio-medical research. Although a precise and unique cut-off value has not been yet found, its role as a flag of immune system homeostasis is well established. NLR has a well-known prognostic value and independently correlates with mortality in the general population and in several specific subsets of disease (sepsis, pneumonia, COVID-19, cancer, etc.). Moreover, NLR was recently considered as part of the decision-making processes concerning the admission/recovery of patients with COVID-19 pneumonia. This review aims to provide an overview of the main use of this biomarker, focusing on the pathophysiology and the molecular basis underlying its central role as a reliable mirror of inflammatory status and adaptive immunity.
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