化学
生物催化
产量(工程)
对映体
对映选择合成
天然产物
对映体过量
组合化学
有机化学
催化作用
离子液体
材料科学
冶金
作者
Danilo Colombo,Alessia Albergati,Erica Elisa Ferrandi,Davide Tessaro,Francesco G. Gatti,Elisabetta Brenna,Daniela Monti,Fabio Parmeggiani
标识
DOI:10.1002/ejoc.202200609
摘要
The combination of a biocatalytic asymmetric C=C reduction with a simple sequence of chemical transformations was implemented in a new chemoenzymatic synthesis of various substituted aryloxyalkanoic acids, used as weed-killing agrochemicals or chiral precursors. By careful selection of the biocatalyst, either enantiomer of the product could be obtained in good yield and moderate to good ee. The method relies on the use of simple and commercially available starting materials, and requires neither purified enzymes nor chromatographic separations.
科研通智能强力驱动
Strongly Powered by AbleSci AI