萜类
人类免疫缺陷病毒(HIV)
生药学
立体化学
传统医学
生物活性
生物
萜烯
二萜
化学
医学
体外
病毒学
生物化学
作者
Di Zhou,Kouharu Otsuki,Mi Zhang,Gang Chen,Zisong Bai,Hui Yu,Takashi Kikuchi,Li Huang,Chin-Ho Chen,Wei Li,Ning Li
标识
DOI:10.1021/acs.jnatprod.1c01195
摘要
Tigliane-type diterpenoids have attracted much attention in drug discovery since they have been reported to exhibit remarkable biological effects, such as tumor-promoting, antineoplastic, and anti-HIV activities. In continuing our efforts to discover novel biologically important diterpenoids from Wikstroemia species, Wikstroemia lichiangensis was investigated phytochemically for the first time. As a result, four new (1–4) and one known (5) tigliane-type diterpenoid were isolated, and their structures were elucidated by spectroscopic data analysis. Tiglianes (1–5) showed potent anti-HIV activity against HIV-1 infection of MT4 lymphocytes with IC50 values of 1.1–65.4 nM.
科研通智能强力驱动
Strongly Powered by AbleSci AI