日冕(行星地质学)
蛋白质吸附
纳米技术
化学
材料科学
生物物理学
化学物理
物理
吸附
生物
物理化学
天体生物学
维纳斯
作者
Pierre‐Luc Latreille,Marine Le Goas,Sina Salimi,Jordan Robert,Grégory De Crescenzo,Daria C. Boffito,Vincent A. Martinez,Patrice Hildgen,Xavier Banquy
出处
期刊:ACS Nano
[American Chemical Society]
日期:2022-02-09
卷期号:16 (2): 1689-1707
被引量:39
标识
DOI:10.1021/acsnano.1c05901
摘要
This Review aims to provide a systematic analysis of the literature regarding ongoing debates in protein corona research. Our goal is to portray the current understanding of two fundamental and debated characteristics of the protein corona, namely, the formation of mono- or multilayers of proteins and their binding (ir)reversibility. The statistical analysis we perform reveals that these characterisitics are strongly correlated to some physicochemical factors of the NP-protein system (particle size, bulk material, protein type), whereas the technique of investigation or the type of measurement (in situ or ex situ) do not impact the results, unlike commonly assumed. Regarding the binding reversibility, the experimental design (either dilution or competition experiments) is also shown to be a key factor, probably due to nontrivial protein binding mechanisms, which could explain the paradoxical phenomena reported in the literature. Overall, we suggest that to truly predict and control the protein corona, future efforts should be directed toward the mechanistic aspects of protein adsorption.
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