梨孢属
化学
喹啉
抗真菌
苯
戒指(化学)
杀菌剂
药物化学
立体化学
有机化学
微生物学
植物
生物
作者
Yue-Ming Fang,Ruirui Zhang,Zhonghua Shen,Cheng‐Xia Tan,Jian‐Quan Weng,Tian‐Ming Xu,Xinghai Liu,Hongying Huang,Hong‐Ke Wu
出处
期刊:Letters in Drug Design & Discovery
[Bentham Science]
日期:2018-12-01
卷期号:15 (12): 1314-1318
被引量:18
标识
DOI:10.2174/1570180815666180313121735
摘要
Background: A series of new 6-(tert-butyl)-8-chloro-2,3-dimethyl quinoline derivatives were designed and synthesized. Results: The primarily antifungal assay results indicated that all of them exhibited excellent protective efficacy (100%) against Pyricularia oryae at 100 ppm, except compound 2m (90%). Among them, the compound 2p (6-(tert-butyl)-8-chloro-2,3-dimethylquinolin-4-yl(2-chloro-5- (trifluoromethyl)benzyl)carbonate) possessed the highest fungicidal efficacy against Pyricularia oryae, even at 10 ppm. Conclusion: The structure-activity relationship showed that when the 2-position of benzene ring was substituted by F or Cl, the compound possessed good antifungal activity against Pyricularia oryae.
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