自愈水凝胶
甲基丙烯酸缩水甘油酯
材料科学
乙二醇
聚合物
生物相容性
丙烯酸酯
甲基丙烯酸酯
原子转移自由基聚合
共聚物
高分子化学
PEG比率
聚合
化学工程
自由基聚合
复合材料
经济
冶金
工程类
财务
作者
Qian Xu,A Sigen,Peter McMichael,Jack Creagh-Flynn,Daohong Zhou,Yongsheng Gao,Xin Li,Xi Wang,Wenxin Wang
出处
期刊:ACS Macro Letters
[American Chemical Society]
日期:2018-04-09
卷期号:7 (5): 509-513
被引量:38
标识
DOI:10.1021/acsmacrolett.8b00138
摘要
Conventional wound healing materials suffer from low efficiency, poor mechanical strength, and nontunable properties. Responsive hydrogels are appealing candidates for tissue engineering. Herein, we developed a double-cross-linked hydrogel system composed of hyperbranched PEG-based polymer, comprising pre-cross-linked acetal structure and numerous terminal acrylate groups, which can form hydrogels in situ and can be further strengthened by UV irradiation. The hyperbranched glycidyl methacrylate-co-poly(ethylene glycol) diacrylate polymers (HB-GMA-PEGs) were first synthesized via in situ deactivation enhanced atom transfer radical polymerization (DE-ATRP). A series of pre-cross-linked materials were achieved after postfunctionalization. The material can absorb a high amount of water to form hydrogels, and the gel stiffness was evaluated in detail before and after UV irradiation. The in vitro cytotoxicity experiments were conducted with the resulting materials and have demonstrated their good biocompatibility. The results indicate that this type of hydrogel with high water uptake capacity has appealing potential as a responsive biomaterial for wound closure.
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