Lipid lowering effect of synthetic phenolic compound in a high- fat diet (HFD) induced hyperlipidemic mice

Hyperlipidemia is the major risk factor of arteriosclerosis, coronary heart diseases and death.Phenolic compounds have been shown to offer the protection against cardiovascular complications.In the present study, we studied the effect of semisynthetic phenolic compounds on the hyperlipidemic mice fed with high fat diet (cholesterol, cholic acid and peanut oil).Phenolic compounds were mixed with HFD and the dose of the test compounds were 1 0mg/kg for 6 weeks.After 6 weeks, the average body weight of lab diet, HFD, standard and test compounds were evaluated.Average body weight of test compound 1, test compound 2 and test compound 3 showed insignificant results (P>1) as compared to the standard drug (Atorvastatin in this study).The liver weight of mice increased (P>1) in all treatment groups relative to standard drug fed group.The plasma lipids such as triglyceride and LDL-cholesterol were found to be increased (P>1) in Test compound 1, test compound 2 , test compound 3 and HFD fed mice when compared to that of standard drug ( Atorvastatin) fed mice.But high-density lipoprotein (HDL) cholesterol increased in standard when compared to that of lab diet fed mice, HFD and test compounds.In conclusion, the supplementation of semi synthetic phenolic compounds may have a weak potential of hypolipidemic effect on mice fed high-fat diet.