水通道蛋白
脉络丛
水通道蛋白4
视神经脊髓炎
神经科学
背根神经节
脑脊液
神经系统
星形胶质细胞
分泌物
生物
细胞生物学
脊髓
中枢神经系统
病理
医学
抗体
免疫学
内分泌学
作者
Marios C. Papadopoulos,A. S. Verkman
摘要
The aquaporins (AQPs) are plasma membrane water-transporting proteins. AQP4 is the principal member of this protein family in the CNS, where it is expressed in astrocytes and is involved in water movement, cell migration and neuroexcitation. AQP1 is expressed in the choroid plexus, where it facilitates cerebrospinal fluid secretion, and in dorsal root ganglion neurons, where it tunes pain perception. The AQPs are potential drug targets for several neurological conditions. Astrocytoma cells strongly express AQP4, which may facilitate their infiltration into the brain, and the neuroinflammatory disease neuromyelitis optica is caused by AQP4-specific autoantibodies that produce complement-mediated astrocytic damage.
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