Orthogonal experiment was used to analyze the energy consumption of air conditioning system, which belongs to four typical passenger stations in four regions, including severe cold region, cold region, hot summer and cold winter region, hot summer and warm winter region. By this means, the order of influencing factors on air-conditioning energy consumption was obtained. Orthogonal experimental data was studied using variance analysis method and the significant factors on air-conditioning energy consumption were also obtained, which will contribute to energy conservation in railway passenger stations.