TACE-dependent amphiregulin release is induced by IL-1  and promotes cell invasion in fibroblast-like synoviocytes in rheumatoid arthritis

AREG and TACE expression were up-regulated by IL-1β and their activations on FLS-RA lead to the matrix degradation by inducing MMP-1 and cadherin-11 production. TACE activity is necessary for IL-1β-induced AREG release. Our results demonstrate that IL-1β-induced AREG release may be involved in the pathogenesis of RA.